Mimusops elengi bark possesses cardiotonic activity as per Ayurvedic books and literature. Present study was carried out to find better and safer herbal cardiotonic alternate of digoxin by evaluating cardiotonic activity of ethanolic extract of bark of Mimusops elengi. The present study was carried out to evaluate positive inotropic effects of extract of bark of Mimusops elengi. Cardiotonic activity of ethanolic extract of the bark of Mimusops elengi Linn was studied against 1/4th calcium chloride induced congestive heart failure in isolated perfused rat heart method. Biochemical study of 15 days for evaluation of cardiac activity of ethanolic extract of Mimusops elengi bark on cardiac enzymes and cytosolic Ca2+ level was also performed. Ethanolic extract of Mimusops elengi showed significant (p<0.001) increased in force of contraction and cardiac output in hypodynamic heart preparations. It significantly increased cytoplasmic Ca2+ level after 15 day treatment but didn’t alter cardiac enzymes level i.e. didn’t alter normal physiology of heart. Present research work emphasizes cardiotonic potential and therapeutic usefulness of bark of Mimusops elengi as better alternate of digoxin in management of congestive heart failure.
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